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Дата: Понедельник, 06.10.2014, 23:30 | Сообщение # 1532

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Дата: Вторник, 14.10.2014, 13:28 | Сообщение # 1533

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Дата: Пятница, 31.10.2014, 23:45 | Сообщение # 1534

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Дата: Вторник, 18.11.2014, 20:53 | Сообщение # 1535

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Дата: Четверг, 20.11.2014, 22:28 | Сообщение # 1536

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Дата: Понедельник, 01.12.2014, 13:26 | Сообщение # 1539

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Дата: Вторник, 06.01.2015, 09:36 | Сообщение # 1540

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Дата: Вторник, 06.01.2015, 11:27 | Сообщение # 1541

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Дата: Среда, 21.01.2015, 16:31 | Сообщение # 1542

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Vancomycin INN /v??k??ma?s?n/ is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by means of Gram-positive bacteria. Vancomycin was maiden eremitical in 1953 at Eli Lilly, from a begrime test nonchalant from the interior jungles of Borneo by a missionary. It is a as a consequence occurring antibiotic made past the soil bacterium Actinobacteria species Amycolatopsis orientalis(once upon a time designated Nocardia orientalis). It is a complex chemical compound and an archetype of a comparatively rare haloorganic reasonable compound, containing two covalently bonded chlorine atoms.
The unite was industrially produced at near fermentation and assumed the generic honour vancomycin, derived from the phrase "vanquish." The native sign for vancomycin was in behalf of the treatment ofpenicillin-resistant Staphylococcus aureus, a consume kept alive for diverse years sooner than the fait accompli that compound had to be given intravenously and that being so provided bacteria fewer opportunities to evolve defences underground, and the the poop indeed that organisms were extent slow to evolve to adapt to it, even in experiments.
Against assorted years since its prime consume, vancomycin had traditionally been unsocial as a psychedelic of "model repair to" deserved to near the start observations of its nephrotoxicity and ototoxicity as well as its intravenous dosing requirements.[1 - Recently, notwithstanding, vancomycin against organisms are attractive common. As a consequence, vancomycin is increasingly being displaced from this responsibility during newer antibiotics such as linezolid(Zyvox), daptomycin (Cubicin), and quinupristin/dalfopristin (Synercid).
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Vancomycin was foremost individual in 1953 by Edmund Kornfeld (working at Eli Lilly) from a blacken sampling at ease from the local jungles of Borneo by way of a missionary.[2 - The organism that produced it was in the end named Amycolatopsis orientalis.[3 - The case implication for vancomycin was in search the treatment of penicillin-resistant Staphylococcus aureus.[3 - [4 -
The go together was initially called compound 05865, but was eventually prearranged the generic namevancomycin, derived from the span of time "vanquish".[3 - A person service better that was fast ostensible is that staphylococci did not bare significant resistance ignoring serial verse in enlightenment media containing vancomycin. The sudden condition of penicillin irregulars by staphylococci led to the mix's being fast-tracked exchange for endorsement before the Food and Drug Delivery (FDA) in 1958. Eli Lilly first marketed vancomycin hydrochloride subsumed under the work label Vancocin[4 - and as COVANC from Nucleus, India.[citation needed -
Vancomycin on no account became the first-line treatment for the treatment of Staphylococcus aureus for a variety of reasons:
1. It possesses meagre uttered bioavailability; it sine qua non be conceded intravenously instead of most infections.
2. β-Lactamase-resistant semi-synthetic penicillins such as methicillin (and its successors,nafcillin and cloxacillin) were afterward developed, which secure bettor vocation against non-MRSA staphylococci.
3. Inopportune trials old early impure forms of vancomycin ("Mississippi gombo"), which were found to be toxic to the ears and to the kidneys;[5 - these findings led to vancomycin's being relegated to the state of a panacea of last resort.[4 -
In 2004, Eli Lilly licensed Vancocin to ViroPharma in the U.S., Flynn Pharma in the UK, and Aspen Pharmacare in Australia. The physical expired in the initially 1980s; the FDA authorized the sale of distinct generic versions in the USA, including from manufacturers Bioniche Pharma, Baxter Healthcare, Sandoz, Akorn Strides and Hospira.[6 -
An vocal cast of vancomycin was from the outset approved nearby the FDA in 1986 with a view the treatment of Clostridium difficile induced pseudomembranous colitis. It is not orally buried into the blood and remains in the gastrointestinal tract to eradicate C. difficile. This product is currently marketed by ViroPharmain the USA.[7 -
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Дата: Пятница, 23.01.2015, 11:56 | Сообщение # 1543

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Дата: Понедельник, 09.02.2015, 11:57 | Сообщение # 1545

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